Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update

Olujimi A. Ajijola; Tolga Aksu; Rishi Arora; Italo Biaggioni; Peng Sheng Chen; Gaetano De Ferrari; Veronica Dusi; Marat Fudim; Jeffrey J. Goldberger; Alexander L. Green; Neil Herring; Sahib S. Khalsa; Rajesh Kumar; Edward Lakatta; Reena Mehra; Christian Meyer; Sunny Po; Stavros Stavrakis; Virend K. Somers; Alex Y. Tan; Miguel Valderrabano; Kalyanam Shivkumar

doi:10.1113/JP284741

Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update

Olujimi A. Ajijola, Tolga Aksu, Rishi Arora, Italo Biaggioni, Peng Sheng Chen, Gaetano De Ferrari, Veronica Dusi, Marat Fudim, Jeffrey J. Goldberger, Alexander L. Green, Neil Herring, Sahib S. Khalsa, Rajesh Kumar, Edward Lakatta, Reena Mehra, Christian Meyer, Sunny Po, Stavros Stavrakis, Virend K. Somers, Alex Y. TanMiguel Valderrabano, Kalyanam Shivkumar

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The intricate role of the autonomic nervous system (ANS) in regulating cardiac physiology has long been recognized. Aberrant function of the ANS is central to the pathophysiology of cardiovascular diseases. It stands to reason, therefore, that neuroscience-based cardiovascular therapeutics hold great promise in the treatment of cardiovascular diseases in humans. A decade after the inaugural edition, this White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology and pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases. (Figure presented.).

Original language	English (US)
Pages (from-to)	1781-1839
Number of pages	59
Journal	Journal of Physiology
Volume	603
Issue number	7
DOIs	https://doi.org/10.1113/JP284741
State	Published - Mar 31 2025

Keywords

arrhythmias
autonomic neuroscience
cardiovascular
heart failure
neurocardiology
neurophysiology
parasympathetic
sympathetic

ASJC Scopus subject areas

Physiology

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10.1113/JP284741

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Ajijola, O. A., Aksu, T., Arora, R., Biaggioni, I., Chen, P. S., De Ferrari, G., Dusi, V., Fudim, M., Goldberger, J. J., Green, A. L., Herring, N., Khalsa, S. S., Kumar, R., Lakatta, E., Mehra, R., Meyer, C., Po, S., Stavrakis, S., Somers, V. K., ... Shivkumar, K. (2025). Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update. Journal of Physiology, 603(7), 1781-1839. https://doi.org/10.1113/JP284741

Ajijola, OA, Aksu, T, Arora, R, Biaggioni, I, Chen, PS, De Ferrari, G, Dusi, V, Fudim, M, Goldberger, JJ, Green, AL, Herring, N, Khalsa, SS, Kumar, R, Lakatta, E, Mehra, R, Meyer, C, Po, S, Stavrakis, S, Somers, VK, Tan, AY, Valderrabano, M & Shivkumar, K 2025, 'Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update', Journal of Physiology, vol. 603, no. 7, pp. 1781-1839. https://doi.org/10.1113/JP284741

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abstract = "The intricate role of the autonomic nervous system (ANS) in regulating cardiac physiology has long been recognized. Aberrant function of the ANS is central to the pathophysiology of cardiovascular diseases. It stands to reason, therefore, that neuroscience-based cardiovascular therapeutics hold great promise in the treatment of cardiovascular diseases in humans. A decade after the inaugural edition, this White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology and pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases. (Figure presented.).",

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Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update

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Keywords

ASJC Scopus subject areas

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