Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

Kalyanam Shivkumar; Olujimi A. Ajijola; Inder Anand; J. Andrew Armour; Peng Sheng Chen; Murray Esler; Gaetano M. De Ferrari; Michael C. Fishbein; Jeffrey J. Goldberger; Ronald M. Harper; Michael J. Joyner; Sahib S. Khalsa; Rajesh Kumar; Richard Lane; Aman Mahajan; Sunny Po; Peter J. Schwartz; Virend K. Somers; Miguel Valderrabano; Marmar Vaseghi; Douglas P. Zipes

doi:10.1113/JP271870

Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

Kalyanam Shivkumar, Olujimi A. Ajijola, Inder Anand, J. Andrew Armour, Peng Sheng Chen, Murray Esler, Gaetano M. De Ferrari, Michael C. Fishbein, Jeffrey J. Goldberger, Ronald M. Harper, Michael J. Joyner, Sahib S. Khalsa, Rajesh Kumar, Richard Lane, Aman Mahajan, Sunny Po, Peter J. Schwartz, Virend K. Somers, Miguel Valderrabano, Marmar VaseghiDouglas P. Zipes

Research output: Contribution to journal › Article › peer-review

233 Scopus citations

Abstract

Abstract: The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.

Original language	English (US)
Pages (from-to)	3911-3954
Number of pages	44
Journal	Journal of Physiology
Volume	594
Issue number	14
DOIs	https://doi.org/10.1113/JP271870
State	Published - Jul 15 2016

ASJC Scopus subject areas

Physiology

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Shivkumar, K., Ajijola, O. A., Anand, I., Armour, J. A., Chen, P. S., Esler, M., De Ferrari, G. M., Fishbein, M. C., Goldberger, J. J., Harper, R. M., Joyner, M. J., Khalsa, S. S., Kumar, R., Lane, R., Mahajan, A., Po, S., Schwartz, P. J., Somers, V. K., Valderrabano, M., ... Zipes, D. P. (2016). Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. Journal of Physiology, 594(14), 3911-3954. https://doi.org/10.1113/JP271870

Shivkumar, K, Ajijola, OA, Anand, I, Armour, JA, Chen, PS, Esler, M, De Ferrari, GM, Fishbein, MC, Goldberger, JJ, Harper, RM, Joyner, MJ, Khalsa, SS, Kumar, R, Lane, R, Mahajan, A, Po, S, Schwartz, PJ, Somers, VK, Valderrabano, M, Vaseghi, M & Zipes, DP 2016, 'Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics', Journal of Physiology, vol. 594, no. 14, pp. 3911-3954. https://doi.org/10.1113/JP271870

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abstract = "Abstract: The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.",

author = "Kalyanam Shivkumar and Ajijola, {Olujimi A.} and Inder Anand and Armour, {J. Andrew} and Chen, {Peng Sheng} and Murray Esler and {De Ferrari}, {Gaetano M.} and Fishbein, {Michael C.} and Goldberger, {Jeffrey J.} and Harper, {Ronald M.} and Joyner, {Michael J.} and Khalsa, {Sahib S.} and Rajesh Kumar and Richard Lane and Aman Mahajan and Sunny Po and Schwartz, {Peter J.} and Somers, {Virend K.} and Miguel Valderrabano and Marmar Vaseghi and Zipes, {Douglas P.}",

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AU - Chen, Peng Sheng

AU - Esler, Murray

AU - De Ferrari, Gaetano M.

AU - Fishbein, Michael C.

AU - Goldberger, Jeffrey J.

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AU - Joyner, Michael J.

AU - Khalsa, Sahib S.

AU - Kumar, Rajesh

AU - Lane, Richard

AU - Mahajan, Aman

AU - Po, Sunny

AU - Schwartz, Peter J.

AU - Somers, Virend K.

AU - Valderrabano, Miguel

AU - Vaseghi, Marmar

AU - Zipes, Douglas P.

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AB - Abstract: The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.

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Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

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