Clinical manifestations of HIV infection in the HAART era

A notable change in the spectrum of clinical manifestations in HIV-infected subjects has been recognized over the past few years. The expanded use of HAART and the increased longevity of the HIV-infected population are the main factors accounting for this change. While the incidence of classical OI occuring in severely immunosuppressed patients has declined dramatically, conditions linked to the use or removal of antiretroviral agents are often seen nowadays. Likewise, complications derived from concomitant diseases such as chronic viral hepatitis and tumors are now more relevant due to the longer life expectancy of HIV-infected individuals.