TY - JOUR
T1 - Clinical Implications of the ISCHEMIA Trial
T2 - Invasive vs Conservative Approach in Stable Coronary Disease
AU - Choudhary, Jamal
AU - Chiu, Sarah
AU - Bhugra, Priyanka
AU - Bikdeli, Behnood
AU - Supariwala, Azhar
AU - Jauhar, Rajiv
AU - Chatterjee, Saurav
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
PY - 2021/3/11
Y1 - 2021/3/11
N2 - PURPOSE OF REVIEW: To identify key strengths and weaknesses of the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial and explore its clinical implications in patients with stable ischemic heart disease.RECENT FINDINGS: Previous studies have shown inconsistent benefit of early angiography and revascularization in patients with stable ischemic heart disease. The ISCHEMIA trial showed no significant reduction in mortality or cardiovascular outcomes in patients undergoing early angiography and revascularization with guideline-directed medical therapy compared to patients on medical therapy alone in specific patient population with stable coronary artery disease. The ISCHEMIA trial provides insights into invasive versus pharmacological treatment for patients with stable ischemic heart disease. Though it may have reduced applicability given its broad exclusion criteria, it offers useful information about the utility of non-invasive imaging modalities for selecting optimal revascularization candidates.
AB - PURPOSE OF REVIEW: To identify key strengths and weaknesses of the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial and explore its clinical implications in patients with stable ischemic heart disease.RECENT FINDINGS: Previous studies have shown inconsistent benefit of early angiography and revascularization in patients with stable ischemic heart disease. The ISCHEMIA trial showed no significant reduction in mortality or cardiovascular outcomes in patients undergoing early angiography and revascularization with guideline-directed medical therapy compared to patients on medical therapy alone in specific patient population with stable coronary artery disease. The ISCHEMIA trial provides insights into invasive versus pharmacological treatment for patients with stable ischemic heart disease. Though it may have reduced applicability given its broad exclusion criteria, it offers useful information about the utility of non-invasive imaging modalities for selecting optimal revascularization candidates.
KW - Cardiac catheterization
KW - Guideline-directed medical therapy
KW - Ischemic heart disease
KW - Revascularization
KW - Coronary Artery Disease/diagnostic imaging
KW - Myocardial Ischemia/therapy
KW - Coronary Angiography
KW - Ischemia
KW - Humans
KW - Coronary Artery Bypass
KW - Myocardial Revascularization
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U2 - 10.1007/s11886-021-01470-x
DO - 10.1007/s11886-021-01470-x
M3 - Review article
C2 - 33704597
AN - SCOPUS:85102376123
SN - 1523-3782
VL - 23
SP - 43
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 5
M1 - 43
ER -