Clinical Impact of Tricuspid Regurgitation on Transcatheter Edge-to-Edge Mitral Valve Repair for Mitral Regurgitation

Kalyan R. Chitturi, Bhaskar Bhardwaj, Ghulam Murtaza, Poorna R. Karuparthi, Nadeen N. Faza, Sachin S. Goel, Michael J. Reardon, Neal S. Kleiman, Kul Aggarwal

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objectives: This study aimed to evaluate whether baseline tricuspid regurgitation (TR) impacted clinical outcomes after mitral valve transcatheter edge-to-edge repair (M-TEER) for severe secondary mitral regurgitation (MR). Background: Baseline TR is common among patients undergoing M-TEER for secondary MR, although its impact on clinical outcomes is unclear. Methods: The Cochrane Library, PubMed/MEDLINE, and Google Scholar were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines from January 1, 2011 through January 31, 2021. Randomized controlled trials and nonrandomized prospective studies that evaluated baseline TR by echocardiography before M-TEER for MR were included. The primary outcome was a composite of mortality and heart failure hospitalization (HFH) at 1-year. Results: A total of 5 studies (n = 1395 patients) were included in the primary analysis. Concurrent moderate/severe TR was associated with a worse 1 year composite of all-cause mortality and HFH (OR: 2.13; 95% CI: 1.12–4.05; p = 0.02) after M-TEER for severe MR. In studies that reported TR grade pre- and post-M-TEER for severe MR, 32% of patients with moderate-to-severe baseline TR had a reduction in TR severity after the intervention. Conclusions: Baseline moderate-to-severe TR was associated with increased 1-year mortality and heart failure hospitalizations among patients undergoing M-TEER. Further randomized studies are needed to assess the interaction of TR among patients undergoing M-TEER.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalCardiovascular Revascularization Medicine
StatePublished - Aug 2022


  • Heart failure
  • Mitral valve disease
  • Percutaneous intervention
  • Structural heart disease intervention
  • Transcatheter edge-to-edge repair
  • Tricuspid regurgitation
  • Prospective Studies
  • Humans
  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Mitral Valve Insufficiency/surgery
  • Tricuspid Valve Insufficiency/surgery
  • Heart Failure/therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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