Clinical case of the month. A rare case of Budd Chiari syndrome.

Theepa Thayalakulasingam, Rehan Mohammed, Shibu Varughese, Arthur W. Zieske, David L. Smith, Lee S. Engel, Brian Boulmay, Fred A. Lopez

Research output: Contribution to journalArticle

Abstract

Budd Chiari syndrome is a rare disorder resulting from hepatic venous outflow tract obstruction anywhere from the small hepatic veins to the suprahepatic inferior vena cava. This patient has a hypercoagulable state secondary to heterozygous mutation of factor V and the JAK2 mutation and is being anticoagulated. We hypothesize that the low protein C and low antithrombin III levels seen in this patient resulted from decreased synthetic function of the liver and were not indicative of actual deficiencies. Indeed, reports of coexisting protein C and antithrombin III deficiencies are not existent in the literature and likely are not compatible with life. All patients with BCS warrant a hypercoagulable work up and JAK2 mutation is increasingly recognized as a contributing factor, even in those patients without obvious signs of polycythemia vera.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalThe Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
Volume163
Issue number5
StatePublished - Sep 1 2011

ASJC Scopus subject areas

  • Medicine(all)

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