Clinical burden of illness in patients with neuroendocrine tumors

Gregory P. Hess, Chi Chang Chen, Zhimei Liu, James C. Yao, Alexandria T. Phan, Jerrold W. Hill

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


OBJECTIVE: The objective of this study was to evaluate the incremental risk of morbidities affecting the cardiovascular, hepatic, gastrointestinal, skeletal, and neuropsychiatric systems in patients with neuroendocrine tumors (NETs) compared with a noncancer cohort. METHODS: In a retrospective, matched-control study using US claims databases, noncancer control subjects (n = 3524) were matched 2:1 with patients with newly diagnosed NET (n = 1762) on age, sex, region, hospital data availability, and index year. Rates of select morbidities were compared between patients with NET and control subjects. Incremental risks were analyzed using logistic regressions adjusting for baseline characteristics. RESULTS: In the first 3 years after diagnosis in patients with NET versus matched control subjects without cancer, (1) the adjusted risk of cardiovascular morbidities was higher (odds ratio [OR], 1.26; P = 0.0206); (2) the adjusted risk of hepatic or gastrointestinal morbidities was higher (OR, 1.95, P < 0.0001); (3) the adjusted risk of osteoporosis/ osteopenia was higher among those 50 years or younger (OR, 3.24; P = 0.0081)(4) the adjusted risk of anxiety/depression was higher among those 65 years or younger (OR, 1.48; P = 0.0210). CONCLUSIONS: Patients with NET have greater clinical burden of disease than matched control subjects with respect to conditions affecting the cardiovascular, hepatic, and gastrointestinal systems. Excess clinical burden of disease with respect to anxiety, depression, osteoporosis, and osteopenia was observed in patients with NET in the younger age groups.

Original languageEnglish (US)
Pages (from-to)1058-1062
Number of pages5
Issue number7
StatePublished - Oct 2012


  • cancer
  • cardiovascular disease
  • comorbidity
  • depression
  • disease burden
  • neuroendocrine tumor
  • osteopenia
  • osteoporosis

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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