Clinical, biochemical, and neuropathologic findings following transplantation of adrenal medulla to the caudate nucleus for treatment of parkinson’s disease

J. Jankovic, Robert G. Grossman, C. Goodman, F. Pirozzolo, L. Schneider, Z. Zhu, P. Scardino, A. J. Garber, S. G. Jhingran, S. Martin

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

We transplanted autologous adrenal medullary tissue into the caudate nucleus of 3 patients with advanced Parkinson’s disease. The 1st patient, a 59-year-old man with parkinsonian symptoms for 15 years, had mild improvement in his motor functioning after the operation. However, his postoperative course was characterized by prolonged drowsiness and complex visual hallucinations. The patient died suddenly 8 months after the transplant, and an autopsy revealed coronary atherosclerosis. Examination of the graft site showed necrotic adrenal medullary tissue surrounded by inflammatory cells. The 2nd patient, a 50-year-old man with a 21-year history of parkinsonian symptoms, improved the most after the procedure. The 3rd patient, a 43-year-old man with 12 years of parkinsonian symptoms, had mild improvement in his motor functioning. CSF homovanillic acid increased postoperatively in the 3 patients, but then returned to preoperative levels in all except the 2nd patient. The anatomic, neurochemical, and physiologic basis for the modest clinical improvement shown in these patients is not yet understood.

Original languageEnglish (US)
Pages (from-to)1227-1234
Number of pages8
JournalNeurology
Volume39
Issue number9
DOIs
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Clinical, biochemical, and neuropathologic findings following transplantation of adrenal medulla to the caudate nucleus for treatment of parkinson’s disease'. Together they form a unique fingerprint.

Cite this