Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis

J. Y. Feng, L. G. Jarlsberg, K. Salcedo, J. Rose, M. Janes, S. Y.G. Lin, D. H. Osmond, K. C. Jost, M. K. Soehnlen, J. Flood, E. A. Graviss, E. Desmond, P. K. Moonan, P. Nahid, P. C. Hopewell, M. Kato-Maeda

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


SETTING: The impact of the genetic characteristics of Mycobacterium tuberculosis on the clustering of multidrug- resistant tuberculosis (MDR-TB) has not been analyzed together with clinical and demographic characteristics. OBJECTIVE : To determine factors associated with genotypic clustering of MDR-TB in a community-based study. DESIGN: We measured the proportion of clustered cases among MDR-TB patients and determined the impact of clinical and demographic characteristics and that of three M. tuberculosis genetic characteristics: lineage, drug resistance-Associated mutations, and rpoA and rpoC compensatory mutations. RESULT S : Of 174 patients from California and Texas included in the study, the number infected by East-Asian, Euro-American, Indo-Oceanic and East-African-Indian M. tuberculosis lineages were respectively 70 (40.2%), 69 (39.7%), 33 (19.0%) and 2 (1.1%). The most common mutations associated with isoniazid and rifampin resistance were respectively katG S315T and rpoB S531L. Potential compensatory mutations in rpoA and rpoC were found in 35 isolates (20.1%). Hispanic ethnicity (OR 26.50, 95%CI 3.73-386.80), infection with an East-Asian M. tuberculosis lineage (OR 30.00, 95%CI 4.20-462.40) and rpoB mutation S531L (OR 4.03, 95%CI 1.05-23.10) were independent factors associated with genotypic clustering. CONCLUS ION: Among the bacterial factors studied, East-Asian lineage and rpoB S531L mutation were independently associated with genotypic clustering, suggesting that bacterial factors have an impact on the ability of M. tuberculosis to cause secondary cases.

Original languageEnglish (US)
Pages (from-to)766-773
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Issue number7
Early online dateMay 16 2017
StatePublished - Jul 1 2017


  • Community-based study
  • Molecular epidemiology
  • Transmission

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


Dive into the research topics of 'Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis'. Together they form a unique fingerprint.

Cite this