TY - JOUR
T1 - Clearance of hepatitis C virus in HIV-infected patients with multiple chronic viral hepatitis
AU - Martín-Carbonero, L.
AU - Barreiro, P.
AU - Jiménez-Galán, G.
AU - García-Berriguete, R.
AU - Núñez, M.
AU - Ríos, P.
AU - González-Lahoz, J.
AU - Soriano, V.
PY - 2007/6
Y1 - 2007/6
N2 - Viral interferences between hepatitis C (HCV) and hepatitis B (HBV) viruses were investigated in a case-control study conducted in 107 human immunodeficiency virus (HIV)-infected patients with HCV antibodies. Overall, 15 (68%) of 22 hepatitis B surface antigen (HBsAg)-positive patients had negative serum HCV-RNA while it occurred in only nine (10%) of 85 HBsAg-negative counterparts (P = 0.02). After adjusting for age, antiretroviral therapy, plasma HIV-RNA and CD4 counts, being HBsAg-positive was strongly associated with having negative serum HCV-RNA (odds ratio: 23; 95% confidence interval: 6-59; P < 0.001). Thus, HBV may favour the elimination of HCV in HIV-infected patients, which may influence liver disease and therapeutic decisions.
AB - Viral interferences between hepatitis C (HCV) and hepatitis B (HBV) viruses were investigated in a case-control study conducted in 107 human immunodeficiency virus (HIV)-infected patients with HCV antibodies. Overall, 15 (68%) of 22 hepatitis B surface antigen (HBsAg)-positive patients had negative serum HCV-RNA while it occurred in only nine (10%) of 85 HBsAg-negative counterparts (P = 0.02). After adjusting for age, antiretroviral therapy, plasma HIV-RNA and CD4 counts, being HBsAg-positive was strongly associated with having negative serum HCV-RNA (odds ratio: 23; 95% confidence interval: 6-59; P < 0.001). Thus, HBV may favour the elimination of HCV in HIV-infected patients, which may influence liver disease and therapeutic decisions.
KW - Hepatitis
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - Human immunodeficiency virus
KW - Liver
UR - http://www.scopus.com/inward/record.url?scp=34248392572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248392572&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2893.2006.00839.x
DO - 10.1111/j.1365-2893.2006.00839.x
M3 - Article
C2 - 17501759
AN - SCOPUS:34248392572
SN - 1352-0504
VL - 14
SP - 392
EP - 395
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
IS - 6
ER -