TY - JOUR
T1 - Clear cell atypical fibroxanthoma arising from vaginal stump
T2 - A case report from unusual location with a history of radiation therapy
AU - Yoo, Su Hyun
AU - An, Soyeon
AU - Kim, Kyu Rae
AU - Ro, Jae
AU - Song, Joon Seon
PY - 2016
Y1 - 2016
N2 - Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of superficial undifferentiated pleomorphic sarcoma, and considered as a tumor of intermediate malignant potential with a relatively indolent clinical behavior. The patient was a 70-year-old female, with a history of a surgery and radiation therapy for rectal adenocarcinoma 10 years ago, who underwent incomplete excision for an exophytic mass on the vaginal stump. Histologically, the tumor was composed of polygonal cells with clear vacuolated cytoplasm and enlarged, vesicular nuclei with prominent nucleoli. The tumor cells were immunopositive for CD10, CD68, CD99, vimentin and procollagen-1, but negative for pan-cytokeratin, HMB45, Melan-A, S100 protein, CD117 and smooth muscle actin. Based on histomorphologic, immunohistochemical, and ultrastructural findings, a diagnosis of CCAFX with histocytic and fibroblastic differentiation was rendered. The tumor recurred during the follow-up period of 4 months. Recognition of CCAFX in the unusual location is important for the proper diagnosis and optimal management.
AB - Clear cell atypical fibroxanthoma (CCAFX) is a rare variant of superficial undifferentiated pleomorphic sarcoma, and considered as a tumor of intermediate malignant potential with a relatively indolent clinical behavior. The patient was a 70-year-old female, with a history of a surgery and radiation therapy for rectal adenocarcinoma 10 years ago, who underwent incomplete excision for an exophytic mass on the vaginal stump. Histologically, the tumor was composed of polygonal cells with clear vacuolated cytoplasm and enlarged, vesicular nuclei with prominent nucleoli. The tumor cells were immunopositive for CD10, CD68, CD99, vimentin and procollagen-1, but negative for pan-cytokeratin, HMB45, Melan-A, S100 protein, CD117 and smooth muscle actin. Based on histomorphologic, immunohistochemical, and ultrastructural findings, a diagnosis of CCAFX with histocytic and fibroblastic differentiation was rendered. The tumor recurred during the follow-up period of 4 months. Recognition of CCAFX in the unusual location is important for the proper diagnosis and optimal management.
KW - Clear cell atypical fibroxanthoma
KW - Undifferentiated pleomorphic sarcoma
KW - Vagina
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M3 - Article
AN - SCOPUS:84969277636
VL - 9
SP - 4049
EP - 4054
JO - International journal of clinical and experimental pathology
JF - International journal of clinical and experimental pathology
SN - 1936-2625
IS - 3
ER -