TY - GEN
T1 - Classification analysis of surface-enhanced laser desorption/ionization mass spectral serum profiles for prostate cancer
AU - Peterson, Leif E.
AU - Hoogeveen, Ron C.
AU - Pownall, Henry J.
AU - Morrisett, Joel D.
PY - 2006
Y1 - 2006
N2 - Classification analysis was performed on 322 SELDI-TOF-MS protein expression profiles for prostate cancer. Feature ranking was based on the F-test, information gain (entropy), and Gini diversity applied in a pairwise, one-against-all, and all-at-once modular form. Classifiers included 4NN, NBC, LDA, LVQ1, SVM, and ANN. 4-class bootstrap (0.632) accuracies were in the range 50-80%, with NBC resulting in the lowest average accuracy (50-66%) and SVM resulting in the greatest average accuracy (71-79%). A 12-peak model with 88% accuracy collapsed into 6 peaks with m/z values of 3460, 4172, 4581, 6890, 14281 and 14696. The peaks identified may be confirmed in the future to be markers of early detection and/or therapy.
AB - Classification analysis was performed on 322 SELDI-TOF-MS protein expression profiles for prostate cancer. Feature ranking was based on the F-test, information gain (entropy), and Gini diversity applied in a pairwise, one-against-all, and all-at-once modular form. Classifiers included 4NN, NBC, LDA, LVQ1, SVM, and ANN. 4-class bootstrap (0.632) accuracies were in the range 50-80%, with NBC resulting in the lowest average accuracy (50-66%) and SVM resulting in the greatest average accuracy (71-79%). A 12-peak model with 88% accuracy collapsed into 6 peaks with m/z values of 3460, 4172, 4581, 6890, 14281 and 14696. The peaks identified may be confirmed in the future to be markers of early detection and/or therapy.
UR - http://www.scopus.com/inward/record.url?scp=38549108112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38549108112&partnerID=8YFLogxK
U2 - 10.1109/ijcnn.2006.246877
DO - 10.1109/ijcnn.2006.246877
M3 - Conference contribution
AN - SCOPUS:38549108112
SN - 0780394909
SN - 9780780394902
T3 - IEEE International Conference on Neural Networks - Conference Proceedings
SP - 3828
EP - 3835
BT - International Joint Conference on Neural Networks 2006, IJCNN '06
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - International Joint Conference on Neural Networks 2006, IJCNN '06
Y2 - 16 July 2006 through 21 July 2006
ER -