CLASSIC: Consistent Longitudinal Alignment and Segmentation for Serial Image Computing

Zhong Xue, Dinggang Shen, Christos Davatzikos

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


This paper proposes a temporally consistent and spatially adaptive longitudinal MR brain image segmentation algorithm, referred to as CLASSIC, which aims at obtaining accurate measurements of rates of change of regional and global brain volumes from serial MR images. The algorithm incorporates image-adaptive clustering, spatiotemporal smoothness constraints, and image warping to jointly segment a series of 3-D MR brain images of the same subject that might be undergoing changes due to development, aging, or disease. Morphological changes, such as growth or atrophy, are also estimated as part of the algorithm. Experimental results on simulated and real longitudinal MR brain images show both segmentation accuracy and longitudinal consistency.

Original languageEnglish (US)
Pages (from-to)388-399
Number of pages12
Issue number2
StatePublished - Apr 1 2006


  • Brain atrophy
  • Brain growth
  • Fuzzy clustering
  • Image segmentation
  • Longitudinal brain image analysis
  • Serial scans
  • Volumetry

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology


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