TY - JOUR
T1 - Circulatory support with paracorporeal pneumatic ventricular assist device (VAD) in infants and children
AU - Ishino, Kozo
AU - Loebe, Matthias
AU - Uhlemann, Frank
AU - Weng, Yuguo
AU - Hennig, Ewald
AU - Hetzer, Roland
N1 - Funding Information:
This study was supported in part by Deutsche Forschungsgemeinschaft grant number DFG He 1669-2:1.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - Objective: The feasibility and efficacy of the pneumatic 'Berlin Heart' ventricular assist device (VAD) were evaluated in 14 pediatric patients with profound cardiogenic shock refractory to conventional therapy. Methods: There were two patient groups. Eleven patients, aged 2 weeks 15 years and weighing 3.2-52 kg received a left ventricular assist device or a biventricular assist device as a bridge to cardiac transplantation (bridge group). Nine of them had liver, kidney, or lung dysfunction before device implantation. Three patients were supported with a biventricular assist device for myocardial recovery (recovery group): a 6-month-old girl for postcardiotomy shock, a 10- month-old girl for allograft failure after cardiac transplantation, and a 4- year-old boy with acute myocarditis. Results: In the bridge group, eight patients were transplanted after a bridge duration of 6-98 days (mean, 32 days) with five long-term survivors. Organ functions were normalized during bridging in all of the transplant recipients. In the recovery group, the first patient was removed from support after 2 days because of irreversible brain damage. The second patient was weaned from biventricular support after 8 days, but suffered from recurrent allograft failure. The third patient received biventricular support for 21 days followed by extracorporeal membrane oxygenation and was subsequently discharged from the hospital. Conclusions: The 'Berlin Heart' VAD can keep selected infants and children with life-threatening heart failure for weeks or months.
AB - Objective: The feasibility and efficacy of the pneumatic 'Berlin Heart' ventricular assist device (VAD) were evaluated in 14 pediatric patients with profound cardiogenic shock refractory to conventional therapy. Methods: There were two patient groups. Eleven patients, aged 2 weeks 15 years and weighing 3.2-52 kg received a left ventricular assist device or a biventricular assist device as a bridge to cardiac transplantation (bridge group). Nine of them had liver, kidney, or lung dysfunction before device implantation. Three patients were supported with a biventricular assist device for myocardial recovery (recovery group): a 6-month-old girl for postcardiotomy shock, a 10- month-old girl for allograft failure after cardiac transplantation, and a 4- year-old boy with acute myocarditis. Results: In the bridge group, eight patients were transplanted after a bridge duration of 6-98 days (mean, 32 days) with five long-term survivors. Organ functions were normalized during bridging in all of the transplant recipients. In the recovery group, the first patient was removed from support after 2 days because of irreversible brain damage. The second patient was weaned from biventricular support after 8 days, but suffered from recurrent allograft failure. The third patient received biventricular support for 21 days followed by extracorporeal membrane oxygenation and was subsequently discharged from the hospital. Conclusions: The 'Berlin Heart' VAD can keep selected infants and children with life-threatening heart failure for weeks or months.
KW - Cardiogenic shock
KW - Heart assist device
KW - Heart transplantation
KW - Pediatrics
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U2 - 10.1016/S1010-7940(97)01149-4
DO - 10.1016/S1010-7940(97)01149-4
M3 - Article
C2 - 9196316
AN - SCOPUS:0030976642
SN - 1010-7940
VL - 11
SP - 965
EP - 972
JO - European Journal of Cardio-thoracic Surgery
JF - European Journal of Cardio-thoracic Surgery
IS - 5
ER -