Circulatory support with paracorporeal pneumatic ventricular assist device (VAD) in infants and children

Kozo Ishino, Matthias Loebe, Frank Uhlemann, Yuguo Weng, Ewald Hennig, Roland Hetzer

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Objective: The feasibility and efficacy of the pneumatic 'Berlin Heart' ventricular assist device (VAD) were evaluated in 14 pediatric patients with profound cardiogenic shock refractory to conventional therapy. Methods: There were two patient groups. Eleven patients, aged 2 weeks 15 years and weighing 3.2-52 kg received a left ventricular assist device or a biventricular assist device as a bridge to cardiac transplantation (bridge group). Nine of them had liver, kidney, or lung dysfunction before device implantation. Three patients were supported with a biventricular assist device for myocardial recovery (recovery group): a 6-month-old girl for postcardiotomy shock, a 10- month-old girl for allograft failure after cardiac transplantation, and a 4- year-old boy with acute myocarditis. Results: In the bridge group, eight patients were transplanted after a bridge duration of 6-98 days (mean, 32 days) with five long-term survivors. Organ functions were normalized during bridging in all of the transplant recipients. In the recovery group, the first patient was removed from support after 2 days because of irreversible brain damage. The second patient was weaned from biventricular support after 8 days, but suffered from recurrent allograft failure. The third patient received biventricular support for 21 days followed by extracorporeal membrane oxygenation and was subsequently discharged from the hospital. Conclusions: The 'Berlin Heart' VAD can keep selected infants and children with life-threatening heart failure for weeks or months.

Original languageEnglish (US)
Pages (from-to)965-972
Number of pages8
JournalEuropean Journal of Cardio-thoracic Surgery
Issue number5
StatePublished - 1997


  • Cardiogenic shock
  • Heart assist device
  • Heart transplantation
  • Pediatrics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


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