Ciprofloxacin for BK viremia prophylaxis in kidney transplant recipients: Results of a prospective, double-blind, randomized, placebo-controlled trial

Samir J. Patel, Richard J. Knight, Samantha A. Kuten, Edward A. Graviss, Duc T. Nguyen, Linda W. Moore, William L. Musick, A. Osama Gaber

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In kidney transplantation, BK virus infection has historically resulted in high rates of graft dysfunction and graft loss. Unlike other opportunistic infections, no therapies have been shown to prevent BK. The purpose of the current study was to evaluate the safety and efficacy of ciprofloxacin for the prevention of BK viremia in kidney transplant recipients. Two hundred kidney transplant recipients were enrolled in a prospective, randomized, double-blind, placebo-controlled trial comparing a 3-month course of ciprofloxacin (n = 133) vs placebo (n = 67) for the prevention of BK viremia. The primary endpoint of BK viremia at month 6 posttransplant occurred in 25 (18.8%) patients in the ciprofloxacin group and 5 (7.5%) in the placebo group (P =.03). Higher rates of BK viremia (23.3% vs 11.9%; P =.06) and BK nephropathy (5.8% vs 1.5%; P =.26) remained at 12 months in the ciprofloxacin group. Ciprofloxacin use was associated with a significantly higher rate of fluoroquinolone-resistant gram-negative infections (83.3% vs 50%; P =.04). A 3-month course of ciprofloxacin was ineffective at preventing BK viremia in kidney transplant recipients and was associated with an increased risk of fluoroquinolone-resistant infections. Clinical trial registration number: NCT01789203.

Original languageEnglish (US)
JournalAmerican Journal of Transplantation
DOIs
StateE-pub ahead of print - Feb 27 2019

Keywords

  • antibiotic prophylaxis
  • antibiotic: antiviral
  • clinical research/practice
  • infection and infectious agents – viral: BK/JC/polyoma
  • kidney transplantation/nephrology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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