CIDEA interacts with liver X receptors in white fat cells

Agné Kulyté, Amanda T. Pettersson, Per Antonson, Britta M. Stenson, Dominique Langin, Jan Ke Gustafsson, Bart Staels, Mikael Rydén, Peter Arner, Jurga Laurencikiene

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) is endogenously expressed in human but not rodent white adipocytes. We performed a bioinformatic analysis of the human CIDEA sequence and found conserved amino-acid motifs involved in binding to nuclear receptors. Protein-protein binding experiments and transactivation assays confirmed that CIDEA binds to liver X receptors and regulates their activity in vitro. Cell fractionation demonstrated that CIDEA localizes to both the cytoplasm and the nucleus in human white adipocytes. The interaction between CIDEA and nuclear receptors could therefore be of importance for the regulation of metabolic processes in human adipose tissue. Structured summary: LXR-beta binds to CIDEA by pull down (View interaction) TIF2 and LXR-beta physically interact by two hybrid (View interaction) LXR-beta binds to RAP250 by pull down (View interaction) CIDEA and LXR-beta physically interact by two hybrid (View interaction)

Original languageEnglish (US)
Pages (from-to)744-748
Number of pages5
JournalFEBS Letters
Volume585
Issue number5
DOIs
StatePublished - Mar 9 2011

Keywords

  • Adipocytes
  • Lipid metabolism
  • Nuclear receptors

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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