Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion

Anne Laure Charles, Alain Meyer, Anne Lejay, James W. Scholey, Nabil Chakfé, Joffrey Zoll, Bernard Geny

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Peripheral artery disease (PAD) is a common circulatory disorder of the lower limb arteries that reduces functional capacity and quality of life of patients. Despite relatively effective available treatments, PAD is a serious public health issue associated with significant morbidity and mortality. Ischemia- reperfusion (I/R) cycles during PAD are responsible for insufficient oxygen supply, mitochondriopathy, free radical production, and inflammation and lead to events that contribute to myocyte death and remote organ failure. However, the chronology of mitochondrial and cellular events during the ischemic period and at the moment of reperfusion in skeletal muscle fibers has been poorly reviewed. Thus, after a review of the basal myocyte state and normal mitochondrial biology, we discuss the physiopathology of ischemia and reperfusion at the mitochondrial and cellular levels. First we describe the chronology of the deleterious biochemical and mitochondrial mechanisms activated by I/R. Then we discuss skeletal muscle I/R injury in the muscle environment, mitochondrial dynamics, and inflammation. A better understanding of the chronology of the events underlying I/R will allow us to identify key factors in the development of this pathology and point to suitable new therapies. Emerging data on mitochondrial dynamics should help identify new molecular and therapeutic targets and develop protective strategies against PAD.

Original languageEnglish (US)
Pages (from-to)C968-C982
JournalAmerican Journal of Physiology - Cell Physiology
Volume310
Issue number11
DOIs
StatePublished - Jun 1 2016

Keywords

  • Ischemia-reperfusion
  • Mitochondria
  • Oxidative stress
  • Peripheral artery disease
  • Skeletal muscle

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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