Abstract

Chronic progressive external ophthalmoplegia (CPEO) is a descriptive term for a heterogenous group of disorders characterized by chronic, progressive, bilateral, and usually symmetric ocular motility deficit and ptosis. Significant pain, proptosis, or pupil involvement are not features of CPEO and should prompt evaluation for alternative etiologies. Mitochondrial DNA mutations are increasingly being recognized as the etiology for CPEO syndromes. Clinicians should recognize the specific syndromes associated with CPEO, characterized by variable systemic, neurologic, or other findings. Treatment is limited, but newer therapies are being investigated.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalCurrent Neurology and Neuroscience Reports
Volume2
Issue number5
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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