Chronic lymphocytic leukemia with hypothalamic invasion

Michael Garofalo, Raj Murali, Ira Halperin, Karnig Magardician, Harry F. Moussouris, Joseph C. Masdeu

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Headaches and a state of confusion developed in a patient with chronic lymphocytic leukemia (CLL). A computed tomography (CT) scan of the head showed a hyperdense lesion in the hypothalamus with obstruction of the foramina of Monro. Leukemic cells with monoclonal lambda B-cell markers were identified in the ventricular fluid at the time of surgical decompression. Similar cells were identified in the peripheral blood. This lesion has not been described as a complication of CLL, a disease that, unlike other leukemias, rarely has central nervous system manifestations.

Original languageEnglish (US)
Pages (from-to)1714-1716
Number of pages3
Issue number8
StatePublished - Oct 15 1989

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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