Chronic kidney disease and diabetes

Ronald Pyram, Abhishek Kansara, Mary Ann Banerji, Lisel Loney-Hutchinson

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Chronic kidney disease has a significant worldwide prevalence affecting 7.2% of the global adult population with the number dramatically increasing in the elderly. Although the causes are various, diabetes is the most common cause of CKD in the United States and an increasing cause of the same worldwide. Therefore, we chose to focus on diabetic chronic kidney disease in this review. The pathogenesis is multifactorial involving adaptive hyperfiltration, advanced glycosylated end-product synthesis (AGES), prorenin, cytokines, nephrin expression and impaired podocyte-specific insulin signaling. Treatments focus on lifestyle interventions including control of hyperglycemia, hypertension and hyperlipidemia as well treatment of complications and preparation for renal replacement therapy. This review examines the current literature on the epidemiology, pathogenesis, complications and treatment of CKD as well as possible areas of future disease intervention.

Original languageEnglish (US)
Pages (from-to)94-103
Number of pages10
JournalMaturitas
Volume71
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • Chronic renal disease
  • Diabetes
  • Glomerular filtration rate
  • Nephropathy
  • Renal failure

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Biochemistry, Genetics and Molecular Biology(all)

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