@article{a53fc34380974ebaa5420d41a2e16fa5,
title = "Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment",
abstract = "Background: Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as to which treatments to use and when. Over a decade ago, a Neurogastroenterology and Motility journal supplement devoted to the investigation and management of constipation was published (Neurogastroenterol Motil 2009;21(Suppl 2):1). In October 2018, the 3rd London Masterclass, entitled “Contemporary management of constipation” was held. The faculty members of this symposium were invited to write two reviews to present a collective synthesis of talks presented and discussions held during this meeting. The first review addresses epidemiology, diagnosis, clinical associations, pathophysiology, and investigation. Purpose: The present is the second of these reviews, providing contemporary perspectives and clinical challenges regarding behavioral, conservative, medical, and surgical treatments for patients presenting with constipation. It includes a management algorithm to guide clinical practice.",
keywords = "IBS-C, algorithm, constipation, treatment",
author = "Maura Corsetti and Steven Brown and Giuseppe Chiarioni and Eirini Dimidi and Thomas Dudding and Anton Emmanuel and Mark Fox and Ford, {Alexander C.} and Pasquale Giordano and Ugo Grossi and Michelle Henderson and Knowles, {Charles H.} and O{\textquoteright}Connell, {P. Ronan} and Quigley, {Eamonn M.M.} and Magnus Simren and Robin Spiller and Kevin Whelan and Whitehead, {William E.} and Williams, {Andrew B.} and Scott, {S. Mark}",
note = "Funding Information: MC acted as consultant for Allergan, Arena, Kyowa Kirin, and Sanofi. AE has served on advisory boards in the last 3 years for Kyowa Kirin, Shionogi, Takeda. MH has received research funding from MacGregor Healthcare Ltd. CK is a paid consultant and speaker for Medtronic Inc. He has consulted in the last 3 years for Coloplast, Enteromed, and Alimentary Health. He has received funding for research activities from Saluda medical, Cook Medical, Exero Medical, and Takeda. He is a member of committees that benefit from industry sponsorship including the Rome Foundation and The GI physiology International Working Group. GC acted as Consulter/Speaker for Kyowa Kirin, Shionogi, and is member of the Anorectal Committee of the Rome Foundation. MRF has acted as a paid consultant and has been paid for speaking and reimbursed for attending a symposiums by Medtronic, Reckitt Benckiser, and Shire Pharmaceuticals. MRF has received funding of research and support of staff by Medtronic, Mui Scientific, Reckitt Benckiser, and Nestle International. MRF has organized educational activities that have been supported by Medtronic, Sandhill Scientific Instruments, and Medical Measurement Systems. MS received unrestricted research grants from Danone Nutricia Research, Glycom, and Ferring Pharmaceuticals; acted as Consultant/Advisory Board member for Danone Nutricia Research, Nestl{\'e}, Menarini, Biocodex, Genetic Analysis AS, Glycom, Arena, and Shire; and was part of the speakers{\textquoteright} bureau of Tillotts, Menarini, Kyowa Kirin, Takeda, Shire, Biocodex, Alimentary Health, AlfaSigma, and Falk Foundation. WW is a former member of the Rome Foundation. He oversaw development of the Rome IV Diagnostic Questionnaire and received a Rome Foundation Grant to validate the diagnostic criteria and design survey questions; these were adapted for the global survey. WW is also the recipient of a National Institute of Health Grant to compare treatments for severe forms of fecal incontinence (U01 DK115575). ED has received an education grant from Alpro, research funding from the British Dietetic Association, Almond Board of California, International Nut and Dried Fruit Council, and Nestec Ltd and has served as a consultant for Puratos. EMMQ served as a consultant to 4D Pharma, Alimentary Health, Allergan, Biocodex, Ironwood, Menarini, Pharmasierra, Salix, and Vibrant; received research support from: 4D Pharma, Takeda, Vibrant, Zealand; and holds equity in Alimentary Health. RS has received research grants from Sanofi‐Aventis and Zespri International and speaker fees from Alfa Wassermann. KW has received research funding from government bodies including National Institute of Health Research and Medical Research Council; from charities including Crohn's and Colitis UK, for Crohn's, the Leona M. and Harry B. Helmsley Charitable Trust, and Kenneth Rainin Foundation; and from industrial sources including Almond Board of California, Clasado Biosciences, Danone, and the International Dried Fruit and Nut Council. KW is the coinventor of a mobile application to support people following dietary restrictions (FoodMaestro). SMS has received honoraria for teaching for Laborie. The remaining authors have not conflict of interest. Publisher Copyright: {\textcopyright} 2020 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jul,
doi = "10.1111/nmo.14070",
language = "English (US)",
volume = "33",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley",
number = "7",
}