Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm

Guilin Tang, Lesley J. Woods, Sa A. Wang, Doreen Brettler, Mary Andersen, Patricia M. Miron, Liberto Pechet, Bruce A. Woda, Suyang Hao

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.

Original languageEnglish (US)
Pages (from-to)1194-1199
Number of pages6
JournalHuman Pathology
Volume40
Issue number8
DOIs
StatePublished - Aug 1 2009

Keywords

  • Chronic basophilic leukemia
  • Cytogenetics
  • Immunophenotype
  • Myeloproliferative neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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