Chromosomal mapping of the human and murine orphan receptors ERRα (ESRRA) and ERRβ (ESRRB) and identification of a novel human ERRα-related pseudogene

R. Sladek, B. Beatty, J. Squire, Neal G. Copeland, D. J. Gilbert, Nancy A. Jenkins, V. Giguère

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The estrogen-related receptors ERRα and ERRβ (formerly ERR1 and ERR2) form a subgroup of the steroid/thyroid/retinoid receptor family. ERRα and ERRβ are homologous to the estrogen receptor and bind similar DNA targets; however, they are unable to activate gene transcription in response to estrogens. We have used interspecific backcross analysis to map the murine Estrra locus to chromosome 19 and Estrrb to mouse chromosome 12. Using fluorescence in situ hybridization, we have mapped the human ESRRA gene to chromosome 11q12-q13 and the human ESRRB gene to chromosome 14q24.3. In addition, we report the isolation of a processed human ERRα pseudogene mapping to chromosome 13q12.1. To our knowledge, this represents the first report of a pseudogene associated with a member of the nuclear receptor superfamily.

Original languageEnglish (US)
Pages (from-to)320-326
Number of pages7
JournalGenomics
Volume45
Issue number2
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Genetics

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