Chromosomal mapping of five mouse g protein γ subunits

Gerald B. Downes, Debra J. Gilbert, Neal G. Copeland, N. Gautam, Nancy A. Jenkins

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Heterotrimeric G proteins, composed of α,β, and γ subunits, transduce signals from transmembrane receptors to a wide range of intracellular effectors. The G protein γ subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific backcross panel, we have determined the mouse chromosomal locations of five γ subunit genes: γ2, γ8, γ10, γ12, and γCone. Combined with previous mapping studies, these data indicate that, with the possible exception of γ1 and γ11, the G protein γ subunit genes are well dispersed within the mouse and human genomes.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalGenomics
Volume57
Issue number1
DOIs
StatePublished - Apr 1 1999

ASJC Scopus subject areas

  • Genetics

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