Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci

J. C. Marine; D. J. Gilbert; E. J. Bellefroid; J. A. Martial; J. N. Ihle; Neal G. Copeland; Nancy A. Jenkins

doi:10.1007/s003359900123

Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci

J. C. Marine, D. J. Gilbert, E. J. Bellefroid, J. A. Martial, J. N. Ihle, Neal G. Copeland, Nancy A. Jenkins

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4 Scopus citations

Abstract

The mammalian genome contains hundreds if not thousands of zinc finger protein (Zfp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play important roles in gene regulation and development. In studies described here, we have used an interspecific mouse back-cross mapping panel to determine the chromosomal location of 15 KRAB-containing zinc finger loci. These loci map to nine different mouse autosomes and the X Chromosome (Chr). Two Chrs, 7 and 9, contain cosegregating pairs of KRAB-containing Zfp genes, indicating that the KRAB-containing Zfp genes have evolved through processes involving regional as well as genome-wide duplication events.

Original language	English (US)
Pages (from-to)	413-416
Number of pages	4
Journal	Mammalian Genome
Volume	7
Issue number	6
DOIs	https://doi.org/10.1007/s003359900123
State	Published - Jan 1 1996

ASJC Scopus subject areas

Genetics

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title = "Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci",

abstract = "The mammalian genome contains hundreds if not thousands of zinc finger protein (Zfp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play important roles in gene regulation and development. In studies described here, we have used an interspecific mouse back-cross mapping panel to determine the chromosomal location of 15 KRAB-containing zinc finger loci. These loci map to nine different mouse autosomes and the X Chromosome (Chr). Two Chrs, 7 and 9, contain cosegregating pairs of KRAB-containing Zfp genes, indicating that the KRAB-containing Zfp genes have evolved through processes involving regional as well as genome-wide duplication events.",

author = "Marine, {J. C.} and Gilbert, {D. J.} and Bellefroid, {E. J.} and Martial, {J. A.} and Ihle, {J. N.} and Copeland, {Neal G.} and Jenkins, {Nancy A.}",

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T1 - Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci

AU - Marine, J. C.

AU - Gilbert, D. J.

AU - Bellefroid, E. J.

AU - Martial, J. A.

AU - Ihle, J. N.

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The mammalian genome contains hundreds if not thousands of zinc finger protein (Zfp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play important roles in gene regulation and development. In studies described here, we have used an interspecific mouse back-cross mapping panel to determine the chromosomal location of 15 KRAB-containing zinc finger loci. These loci map to nine different mouse autosomes and the X Chromosome (Chr). Two Chrs, 7 and 9, contain cosegregating pairs of KRAB-containing Zfp genes, indicating that the KRAB-containing Zfp genes have evolved through processes involving regional as well as genome-wide duplication events.

AB - The mammalian genome contains hundreds if not thousands of zinc finger protein (Zfp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play important roles in gene regulation and development. In studies described here, we have used an interspecific mouse back-cross mapping panel to determine the chromosomal location of 15 KRAB-containing zinc finger loci. These loci map to nine different mouse autosomes and the X Chromosome (Chr). Two Chrs, 7 and 9, contain cosegregating pairs of KRAB-containing Zfp genes, indicating that the KRAB-containing Zfp genes have evolved through processes involving regional as well as genome-wide duplication events.

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Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci

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