Chromosomal location of Evi-1, a common site of ecotropic viral integration of AKXD murine myeloid tumors

M. L. Mucenski, B. A. Taylor, N. G. Copeland, N. A. Jenkins

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myelogenous leukemias, was determined by recombinant inbred and conventional backcross analyses. We mapped Evi-1 to a location approximately 15 cM distal to the carbonic anhydrase locus on murine Chromosome 3. The chromosomal location of the proto-oncogene Nras, and two growth factors, epidermal growth factor (Egf), and the beta subunit of nerve growth factor (Ngfb), which had previously been assigned to Chromosome 3 by somatic cell hybrid analysis, were also determined. The location of Evi-1 is distinct from these three loci and from all other proto-oncogenes, common sites of viral integration, or growth factor loci previously mapped in mouse chromosomes. These results suggest that Evi-1 represents a new locus involved in myeloid disease.

Original languageEnglish (US)
Pages (from-to)219-233
Number of pages15
JournalOncogene Research
Volume2
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Cancer Research

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