Chromosomal localization of the ox-44 (Cd53) leukocyte antigen gene in man and rodents

T. Taguchi; A. Bellacosa; J. Y. Zhou; D. J. Gilbert; P. A. Lazo; N. G. Copeland; N. A. Jenkins; P. N. Tsichlis; J. R. Testa

doi:10.1159/000133580

Chromosomal localization of the ox-44 (Cd53) leukocyte antigen gene in man and rodents

T. Taguchi, A. Bellacosa, J. Y. Zhou, D. J. Gilbert, P. A. Lazo, N. G. Copeland, N. A. Jenkins, P. N. Tsichlis, J. R. Testa

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16 Scopus citations

Abstract

The Ox-44 (CD53) leukocyte antigen contributes to the transduction of CD2- generated signals in T cells and natural killer (NK) cells and has been suggested to play a role in growth regulation. The gene encoding this protein was assigned to the midportion of mouse chromosome 3 by interspecific backcross mapping and to human chromosome region 1p21 → p13.3 and rat chromosome region 2q34 → q41 by fluorescence in situ hybridization. Comparative mapping data presented in this report demonstrate conservation of synteny within the region encompassing this gene in mouse (Cd53), human (CD53), and rat (CD53).

Original language	English (US)
Pages (from-to)	217-221
Number of pages	5
Journal	Cytogenetics and Cell Genetics
Volume	64
Issue number	3-4
DOIs	https://doi.org/10.1159/000133580
State	Published - 1993

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "Chromosomal localization of the ox-44 (Cd53) leukocyte antigen gene in man and rodents",

abstract = "The Ox-44 (CD53) leukocyte antigen contributes to the transduction of CD2- generated signals in T cells and natural killer (NK) cells and has been suggested to play a role in growth regulation. The gene encoding this protein was assigned to the midportion of mouse chromosome 3 by interspecific backcross mapping and to human chromosome region 1p21 → p13.3 and rat chromosome region 2q34 → q41 by fluorescence in situ hybridization. Comparative mapping data presented in this report demonstrate conservation of synteny within the region encompassing this gene in mouse (Cd53), human (CD53), and rat (CD53).",

author = "T. Taguchi and A. Bellacosa and Zhou, {J. Y.} and Gilbert, {D. J.} and Lazo, {P. A.} and Copeland, {N. G.} and Jenkins, {N. A.} and Tsichlis, {P. N.} and Testa, {J. R.}",

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doi = "10.1159/000133580",

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T1 - Chromosomal localization of the ox-44 (Cd53) leukocyte antigen gene in man and rodents

AU - Taguchi, T.

AU - Bellacosa, A.

AU - Zhou, J. Y.

AU - Gilbert, D. J.

AU - Lazo, P. A.

AU - Copeland, N. G.

AU - Jenkins, N. A.

AU - Tsichlis, P. N.

AU - Testa, J. R.

PY - 1993

Y1 - 1993

N2 - The Ox-44 (CD53) leukocyte antigen contributes to the transduction of CD2- generated signals in T cells and natural killer (NK) cells and has been suggested to play a role in growth regulation. The gene encoding this protein was assigned to the midportion of mouse chromosome 3 by interspecific backcross mapping and to human chromosome region 1p21 → p13.3 and rat chromosome region 2q34 → q41 by fluorescence in situ hybridization. Comparative mapping data presented in this report demonstrate conservation of synteny within the region encompassing this gene in mouse (Cd53), human (CD53), and rat (CD53).

AB - The Ox-44 (CD53) leukocyte antigen contributes to the transduction of CD2- generated signals in T cells and natural killer (NK) cells and has been suggested to play a role in growth regulation. The gene encoding this protein was assigned to the midportion of mouse chromosome 3 by interspecific backcross mapping and to human chromosome region 1p21 → p13.3 and rat chromosome region 2q34 → q41 by fluorescence in situ hybridization. Comparative mapping data presented in this report demonstrate conservation of synteny within the region encompassing this gene in mouse (Cd53), human (CD53), and rat (CD53).

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Chromosomal localization of the ox-44 (Cd53) leukocyte antigen gene in man and rodents

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