Chromosomal localization of the ox-44 (Cd53) leukocyte antigen gene in man and rodents

T. Taguchi, A. Bellacosa, J. Y. Zhou, D. J. Gilbert, P. A. Lazo, N. G. Copeland, N. A. Jenkins, P. N. Tsichlis, J. R. Testa

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The Ox-44 (CD53) leukocyte antigen contributes to the transduction of CD2- generated signals in T cells and natural killer (NK) cells and has been suggested to play a role in growth regulation. The gene encoding this protein was assigned to the midportion of mouse chromosome 3 by interspecific backcross mapping and to human chromosome region 1p21 → p13.3 and rat chromosome region 2q34 → q41 by fluorescence in situ hybridization. Comparative mapping data presented in this report demonstrate conservation of synteny within the region encompassing this gene in mouse (Cd53), human (CD53), and rat (CD53).

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalCytogenetic and Genome Research
Volume64
Issue number3-4
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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