Chromosomal localization of seven members of the murine TGF-β superfamily suggests close linkage to several morphogenetic mutant loci

Mary E. Dickinson, Michael S. Kobrin, Colleen M. Silan, David M. Kingsley, Monica J. Justice, Duncan A. Miller, Jeffrey D. Ceci, Leslie F. Lock, Angela Lee, Arthur M. Buchberg, Linda D. Siracusa, Karen M. Lyons, Rik Derynck, Brigid L.M. Hogan, Neal G. Copeland, Nancy A. Jenkins

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

Chromosomal locations have been assigned to seven members of the TGF-β superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp-2b2). The results show that the seven members of the TGF-β superfamily map to eight different chromosomes, indicating that the TGF-β family has become widely dispersed during evolution. Five of the eight loci (Tgfb-1, Bmp-2a, Bmp-2b1, Bmp-2b2, Vgr-1) mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations result from defects in TGF-β-related genes.

Original languageEnglish (US)
Pages (from-to)505-520
Number of pages16
JournalGenomics
Volume6
Issue number3
DOIs
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Genetics

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