@article{b9a650a4c83e40178479255837cd99b2,
title = "Chromosomal localization of seven members of the murine TGF-β superfamily suggests close linkage to several morphogenetic mutant loci",
abstract = "Chromosomal locations have been assigned to seven members of the TGF-β superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp-2b2). The results show that the seven members of the TGF-β superfamily map to eight different chromosomes, indicating that the TGF-β family has become widely dispersed during evolution. Five of the eight loci (Tgfb-1, Bmp-2a, Bmp-2b1, Bmp-2b2, Vgr-1) mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations result from defects in TGF-β-related genes.",
author = "Dickinson, {Mary E.} and Kobrin, {Michael S.} and Silan, {Colleen M.} and Kingsley, {David M.} and Justice, {Monica J.} and Miller, {Duncan A.} and Ceci, {Jeffrey D.} and Lock, {Leslie F.} and Angela Lee and Buchberg, {Arthur M.} and Siracusa, {Linda D.} and Lyons, {Karen M.} and Rik Derynck and Hogan, {Brigid L.M.} and Copeland, {Neal G.} and Jenkins, {Nancy A.}",
note = "Funding Information: We thank Philip Avner, George Carlson, Peter D{\textquoteright}Eustachio, Robert Dunn, Roger Ganschow, Tak Mak, Christine Pourcel, T. V. Rajan, Jonathan Stoye, Pierre Tambourin, Shirley Tilghman, John Wozney, and Howard Young for generously providing probes. We thank Michelle Bodamer, Brian Cho, Mary Beth Cybulski, Joanne Diem, Bryn Eagleson, Debra J. Gilbert, Deborah A. Swing, and Reit van der Meer for excellent technical assistance. We thank Linda Brubaker for preparation of the manuscript. We thank T. H. Roderick, M. T. Davisson, A. L. Hillyard, and D. P. Doolittle for granting us permission to publish their composite linkage map. This work was sponsored in part by the National Cancer Institute, DHHS, under Contract NOl-CO-74101 with BRI and by the National Institutes of Health, under Grant ROl EY08000-01 to B.L.M.H. D.M.K. is a Lucille P. Markey Scholar in Biomedical Science. L.F.L. is supported by Damon Runyon-Welter Winchell Cancer Fund Fellowship DRG-918. L.D.S. is the recipient of a National Research Service Award,",
year = "1990",
month = mar,
doi = "10.1016/0888-7543(90)90480-I",
language = "English (US)",
volume = "6",
pages = "505--520",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press",
number = "3",
}