Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping

E. D. Loh, S. R. Broussard, Q. Liu, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, Lee F. Kolakowski

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We report the chromosomal localization in both mouse and human of a novel G-protein-coupled receptor, GPR48, which resembles glycoprotein hormone receptors, that may be implicated in Wilms tumor deletion syndromes such as WAGR. This receptor forms a novel sub-family of glycoprotein hormone-like GPCRs. We have mapped this receptor to human chromosome 11p14→p13 by several approaches, including radiation hybrid and interspecific backcross mapping, and show that GPR48 is close to BDNF. This data differs from the recently published mapping of LGR4 (5q34→q35.1) (Hsu et al., 1998). Additionally, we show that Gpr48 and Bdnf are tightly linked on mouse chromosome 2, in a region with conserved synteny to human 11p14→p13. (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)2-5
Number of pages4
JournalCytogenetics and Cell Genetics
Volume89
Issue number1-2
StatePublished - 2000

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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