Chromosomal localization, embryonic expression, and imprinting tests for Bmp7 on distal mouse chromosome 2

Paul C. Marker, Jennifer A. King, Neal G. Copeland, Nancy A. Jenkins, David M. Kingsley

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Murine Bmp7 has been assigned to distal Chromosome 2 by interspecific backcross mapping. The map location suggests close linkage to classical mouse mutations and places Bmp7 within a chromosome region thought to contain one or more unidentified imprinted genes. A direct test suggests that Bmp7 is not imprinted. An examination of embryonic RNA expression patterns shows that Bmp7 is expressed in a variety of skeletal and nonskeletal tissues. Both embryonic expression patterns and the human chromosomal sublocalization inferred from its mouse location make Bmp7 a candidate for the gene affected in some patients with Holt-Oram syndrome.

Original languageEnglish (US)
Pages (from-to)576-580
Number of pages5
JournalGenomics
Volume28
Issue number3
DOIs
StatePublished - Aug 10 1995

ASJC Scopus subject areas

  • Genetics

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