Chromophobe Renal Cell Carcinoma With Sarcomatoid Transformation

Neil A. Abrahams, Alberto Ayala, Bogdan Czerniak

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


We present a rare case of a chromophobe renal cell carcinoma that progressed to a high-grade spindle cell sarcoma. The tumor affected a 50-year-old man who had presented with right upper quadrant discomfort and hematuria and subsequently underwent a right radical nephrectomy. Microscopically, the tumor was composed of two distinct components, a chromophobe renal cell carcinoma and a sarcomatoid component. The sarcomatoid component had exhibited aggressive behavior by spreading to a regional lymph node. This case report shows that chromophobe carcinoma can develop a sarcomatoid transformation with a high propensity for invasive growth and metastasis.

Original languageEnglish (US)
Pages (from-to)296-299
Number of pages4
JournalAnnals of Diagnostic Pathology
Issue number5
StatePublished - Jan 1 2003


  • Arcomatoid carcinoma
  • Chromophobe carcinoma
  • Kidney morphology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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