Chromatin elimination - An oddity or a common mechanism in differentiation and development?

Malgorzata Kloc, Bozenna Zagrodzinska

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Over many decades, a great number of exceptions from the rule of equal segregation of the chromosomes during cell division have been found in different animal species. The most diversified is the process of chromosome re-arrangement that takes place during the specification of soma versus germ-line cell fate in the embryos from the whole spectrum of animal phyla. In nematodes, copepodes, insects, hagfish, and marsupials, the chromatin/chromosome elimination is a common path of normal cell differentiation and development. This also raises the question of the mechanisms and factors that promote elimination in pre-somatic cell lines and/or inhibit the elimination in the prospective germ cells. We will discuss the possible role of the germ plasm in this process.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalDifferentiation
Volume68
Issue number2-3
DOIs
StatePublished - 2001

Keywords

  • Chromosome elimination
  • Diminution
  • Germ cells
  • Germinal plasm
  • Pole plasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Developmental Biology
  • Cell Biology

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