Chromatin elimination - An oddity or a common mechanism in differentiation and development?

Malgorzata Kloc, Bozenna Zagrodzinska

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Over many decades, a great number of exceptions from the rule of equal segregation of the chromosomes during cell division have been found in different animal species. The most diversified is the process of chromosome re-arrangement that takes place during the specification of soma versus germ-line cell fate in the embryos from the whole spectrum of animal phyla. In nematodes, copepodes, insects, hagfish, and marsupials, the chromatin/chromosome elimination is a common path of normal cell differentiation and development. This also raises the question of the mechanisms and factors that promote elimination in pre-somatic cell lines and/or inhibit the elimination in the prospective germ cells. We will discuss the possible role of the germ plasm in this process.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
Issue number2-3
StatePublished - 2001


  • Chromosome elimination
  • Diminution
  • Germ cells
  • Germinal plasm
  • Pole plasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'Chromatin elimination - An oddity or a common mechanism in differentiation and development?'. Together they form a unique fingerprint.

Cite this