Chondrosarcoma: With updates on molecular genetics

Jae Y. Ro, Mi Jung Kim, Kyung Ja Cho, Alberto G. Ayala

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Chondrosarcoma (CHS) is a malignant cartilage-forming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Based on the morphologic feature alone, a correct diangosis of CHS may be difficult, Therefore, correlation of radiological and clinicopathological features is mandatory in the diagnosis of CHS. The prognosis of CHS is closely related to histologic grading, however, histologic grading may be subjective with high inter-observer variability. In this paper, we present histologic grading system and clinicopathological and radiological findings of conventional CHS. Subtypes of CHSs, such as dedifferentiated, mesenchymal, and clear cell CHSs are also presented. In addition, we introduce updated cytogenetic and molecular genetic findings to expand our understanding of CHS biology. New markers of cell differentiation, proliferation, and cell signaling might offer important therapeutic and prognostic information in near future.

Original languageEnglish (US)
Article number405437
JournalSarcoma
Volume2011
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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