Chondroblastoma-like chondroma of soft tissue: Report of the first case in the base of skull

Kirtee Raparia, Jerry W. Lin, Donald Donovan, Jeffrey T. Vrabec, Qihui Zhai, Alberto A. Ayala, Jae Y. Ro

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Chondroblastoma-like chondroma (CLC) of soft tissue is a rare benign neoplasm that usually involves the soft tissues of the hand. This report describes the first case of CLC of soft tissue arising in the base of the skull. A 33-year-old man was seen with a slow growing mass in the right parotid region of his face. The noncontrast computed tomographic scans showed an 8.5-cm mass with calcifications involving the right masticator space and extending through the bone into the middle cranial fossa. The radiologic differential diagnosis included osteosarcoma, leiomyosarcoma, chondrosarcoma, and giant cell tumor. During surgery, the large lateral skull base tumor appeared to involve the middle and infratemporal fossae and eroded the surrounding bone. Although the tumor was removed piecemeal, total excision was performed. On microscopic examination, the tumor displayed lobules of mature hyaline cartilage with numerous chondroblasts, coarse calcifications including chicken wire calcifications, and scattered osteoclasts. No atypia, mitoses, necrosis, or osteoid formation was seen. The tumor was diagnosed as chondroma with chondroblastoma features of the soft tissue. His postoperative clinical course was uneventful; however, after 7 months, he had a local recurrence identified on follow-up magnetic resonance imaging. He underwent repeat surgical excision of the tumor, which showed similar histology as the previous excision. This large skull based tumor eroding the bone, which clinically and radiologically mimicked a malignant process, was an unusual presentation of a benign cartilaginous neoplasm. Pathologists should be aware that CLC may occur in the base of the skull and this lesion should be differentiated from the other benign or malignant tumors arising in this area. These lesions have a potential for local recurrence; hence, a close follow-up is recommended.

Original languageEnglish (US)
Pages (from-to)298-301
Number of pages4
JournalAnnals of Diagnostic Pathology
Volume17
Issue number3
DOIs
StatePublished - Jun 2013

Keywords

  • Base of skull
  • Chondroblastoma-like chondroma of soft tissue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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