Cholesterol: Can't Live With It, Can't Live Without It

Research output: Contribution to journalReview article

Given its role in many biochemical processes essential to life, cholesterol remains a topic of intense research. Of all the plasma lipids, cholesterol is distinctive because it is a precursor to steroidogenic molecules, some of which regulate metabolism, and its blood concentration in the form of low- and high-density lipoprotein cholesterol (HDL-C) are positive and negative risk factors for atherosclerotic cardiovascular disease (ASCVD). New research, however, has challenged the widely held belief that high HDL-C levels are atheroprotective and is showing that both low and high plasma HDL-C levels confer an increased risk of ASCVD. Furthermore, it is disputing the widely cited mechanism involved in reverse cholesterol transport. This review explores the evolution of cholesterol research starting with the Gofman and Framingham studies, the development of traditional and emerging lipid-lowering therapies, and the role of reverse cholesterol transport in HDL cardioprotection.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalMethodist DeBakey cardiovascular journal
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2019

PMID: 31049144

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Cite this

Standard

Cholesterol : Can't Live With It, Can't Live Without It. / Pownall, Henry J.; Gotto, Antonio.

In: Methodist DeBakey cardiovascular journal, Vol. 15, No. 1, 01.01.2019, p. 9-15.

Research output: Contribution to journalReview article

Harvard

Pownall, HJ & Gotto, A 2019, 'Cholesterol: Can't Live With It, Can't Live Without It' Methodist DeBakey cardiovascular journal, vol. 15, no. 1, pp. 9-15. https://doi.org/10.14797/mdcj-15-1-9

APA

Pownall, H. J., & Gotto, A. (2019). Cholesterol: Can't Live With It, Can't Live Without It. Methodist DeBakey cardiovascular journal, 15(1), 9-15. https://doi.org/10.14797/mdcj-15-1-9

Vancouver

Pownall HJ, Gotto A. Cholesterol: Can't Live With It, Can't Live Without It. Methodist DeBakey cardiovascular journal. 2019 Jan 1;15(1):9-15. https://doi.org/10.14797/mdcj-15-1-9

Author

Pownall, Henry J. ; Gotto, Antonio. / Cholesterol : Can't Live With It, Can't Live Without It. In: Methodist DeBakey cardiovascular journal. 2019 ; Vol. 15, No. 1. pp. 9-15.

BibTeX

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title = "Cholesterol: Can't Live With It, Can't Live Without It",
abstract = "Given its role in many biochemical processes essential to life, cholesterol remains a topic of intense research. Of all the plasma lipids, cholesterol is distinctive because it is a precursor to steroidogenic molecules, some of which regulate metabolism, and its blood concentration in the form of low- and high-density lipoprotein cholesterol (HDL-C) are positive and negative risk factors for atherosclerotic cardiovascular disease (ASCVD). New research, however, has challenged the widely held belief that high HDL-C levels are atheroprotective and is showing that both low and high plasma HDL-C levels confer an increased risk of ASCVD. Furthermore, it is disputing the widely cited mechanism involved in reverse cholesterol transport. This review explores the evolution of cholesterol research starting with the Gofman and Framingham studies, the development of traditional and emerging lipid-lowering therapies, and the role of reverse cholesterol transport in HDL cardioprotection.",
keywords = "atherogenesis, lipid risk factors, lipid therapeutics, lipoproteins, reverse cholesterol transport",
author = "Pownall, {Henry J.} and Antonio Gotto",
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journal = "Methodist DeBakey Cardiovascular Journal",
issn = "1947-6094",
publisher = "Methodist DeBakey Heart & Vascular Center",
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}

RIS

TY - JOUR

T1 - Cholesterol

T2 - Methodist DeBakey Cardiovascular Journal

AU - Pownall, Henry J.

AU - Gotto, Antonio

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Given its role in many biochemical processes essential to life, cholesterol remains a topic of intense research. Of all the plasma lipids, cholesterol is distinctive because it is a precursor to steroidogenic molecules, some of which regulate metabolism, and its blood concentration in the form of low- and high-density lipoprotein cholesterol (HDL-C) are positive and negative risk factors for atherosclerotic cardiovascular disease (ASCVD). New research, however, has challenged the widely held belief that high HDL-C levels are atheroprotective and is showing that both low and high plasma HDL-C levels confer an increased risk of ASCVD. Furthermore, it is disputing the widely cited mechanism involved in reverse cholesterol transport. This review explores the evolution of cholesterol research starting with the Gofman and Framingham studies, the development of traditional and emerging lipid-lowering therapies, and the role of reverse cholesterol transport in HDL cardioprotection.

AB - Given its role in many biochemical processes essential to life, cholesterol remains a topic of intense research. Of all the plasma lipids, cholesterol is distinctive because it is a precursor to steroidogenic molecules, some of which regulate metabolism, and its blood concentration in the form of low- and high-density lipoprotein cholesterol (HDL-C) are positive and negative risk factors for atherosclerotic cardiovascular disease (ASCVD). New research, however, has challenged the widely held belief that high HDL-C levels are atheroprotective and is showing that both low and high plasma HDL-C levels confer an increased risk of ASCVD. Furthermore, it is disputing the widely cited mechanism involved in reverse cholesterol transport. This review explores the evolution of cholesterol research starting with the Gofman and Framingham studies, the development of traditional and emerging lipid-lowering therapies, and the role of reverse cholesterol transport in HDL cardioprotection.

KW - atherogenesis

KW - lipid risk factors

KW - lipid therapeutics

KW - lipoproteins

KW - reverse cholesterol transport

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U2 - 10.14797/mdcj-15-1-9

DO - 10.14797/mdcj-15-1-9

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EP - 15

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JF - Methodist DeBakey Cardiovascular Journal

SN - 1947-6094

IS - 1

ER -

ID: 48903977