TY - JOUR
T1 - Choice reaction time modifiability in dementia and depression
AU - Pirozzolo, Francis J.
AU - Mahurin, Roderick K.
AU - Loring, David W.
AU - Appel, Stanley H.
AU - Maletta, Gabe J.
N1 - Funding Information:
This work was supported by NIH training grant AG 00061, NIH grants NS 07377, and Moody Foundation grant 80-233. The authors would like to thank Scott E. Maxwell for his contributions to the statistical analysis and Beverly White for her assistance in preparation of the manuscript.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - The effects of cognitive impairment resulting from either dementia of the Alzheimer type (DAT) or major depression (pseudodementia) on choice reaction time were examined in two conditions hypothesized to influence group performance selectively. Elderly controls had shorter reaction times than depressed patients who, in turn, were faster than dementia patients in the standard choice reaction time test. Elderly control and depressed subjects responded more quickly under conditions designed to reduce task demands. However, no effect was detected for DAT patients, presumably due to the neural constraints imposed on cognitive functioning in dementia. These results highlight the different etiologies for the intellectual decline in dementia and pseudodementia.
AB - The effects of cognitive impairment resulting from either dementia of the Alzheimer type (DAT) or major depression (pseudodementia) on choice reaction time were examined in two conditions hypothesized to influence group performance selectively. Elderly controls had shorter reaction times than depressed patients who, in turn, were faster than dementia patients in the standard choice reaction time test. Elderly control and depressed subjects responded more quickly under conditions designed to reduce task demands. However, no effect was detected for DAT patients, presumably due to the neural constraints imposed on cognitive functioning in dementia. These results highlight the different etiologies for the intellectual decline in dementia and pseudodementia.
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U2 - 10.3109/00207458508985597
DO - 10.3109/00207458508985597
M3 - Article
C2 - 3997381
AN - SCOPUS:0022051839
SN - 0020-7454
VL - 26
SP - 1
EP - 7
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 1-2
ER -