Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-dependent mechanism

Min P. Kim; Charlotte A. Gaydos; Billie Jo Wood; Justin P. Hardick; Yahong Zhang; Larry M. Wahl

doi:10.1128/IAI.73.1.632-634.2005

Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E₂-dependent mechanism

Min P. Kim, Charlotte A. Gaydos, Billie Jo Wood, Justin P. Hardick, Yahong Zhang, Larry M. Wahl

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Exposure of human monocytes to Chlamydia pneumoniae resulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect of C. pneumoniae on monocyte MMPs was mediated through the induction of prostaglandin E₂. These findings may have implications for atherosclerotic plaque rapture.

Original language	English (US)
Pages (from-to)	632-634
Number of pages	3
Journal	Infection and Immunity
Volume	73
Issue number	1
DOIs	https://doi.org/10.1128/IAI.73.1.632-634.2005
State	Published - Jan 2005

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.73.1.632-634.2005

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title = "Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-dependent mechanism",

abstract = "Exposure of human monocytes to Chlamydia pneumoniae resulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect of C. pneumoniae on monocyte MMPs was mediated through the induction of prostaglandin E2. These findings may have implications for atherosclerotic plaque rapture.",

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AU - Kim, Min P.

AU - Gaydos, Charlotte A.

AU - Wood, Billie Jo

AU - Hardick, Justin P.

AU - Zhang, Yahong

AU - Wahl, Larry M.

PY - 2005/1

Y1 - 2005/1

N2 - Exposure of human monocytes to Chlamydia pneumoniae resulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect of C. pneumoniae on monocyte MMPs was mediated through the induction of prostaglandin E2. These findings may have implications for atherosclerotic plaque rapture.

AB - Exposure of human monocytes to Chlamydia pneumoniae resulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect of C. pneumoniae on monocyte MMPs was mediated through the induction of prostaglandin E2. These findings may have implications for atherosclerotic plaque rapture.

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AN - SCOPUS:11144285378

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JO - Infection and Immunity

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IS - 1

ER -

Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E₂-dependent mechanism

Abstract

ASJC Scopus subject areas

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