Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-dependent mechanism

Min P. Kim, Charlotte A. Gaydos, Billie Jo Wood, Justin P. Hardick, Yahong Zhang, Larry M. Wahl

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Exposure of human monocytes to Chlamydia pneumoniae resulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect of C. pneumoniae on monocyte MMPs was mediated through the induction of prostaglandin E2. These findings may have implications for atherosclerotic plaque rapture.

Original languageEnglish (US)
Pages (from-to)632-634
Number of pages3
JournalInfection and Immunity
Volume73
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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