Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

Yiye Li; Yunlong Zhou; Hai Yan Wang; Sarah Perrett; Yuliang Zhao; Zhiyong Tang; Guangjun Nie

doi:10.1002/anie.201008206

Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

Yiye Li, Yunlong Zhou, Hai Yan Wang, Sarah Perrett, Yuliang Zhao, Zhiyong Tang, Guangjun Nie

Houston Methodist

Research output: Contribution to journal › Article › peer-review

230 Scopus citations

Abstract

Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).

Original language	English (US)
Pages (from-to)	5860-5864
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	26
DOIs	https://doi.org/10.1002/anie.201008206
State	Published - Jun 20 2011

Keywords

autophagy
chirality
cytotoxicity
fluorescence
quantum dots

ASJC Scopus subject areas

General Chemistry
Catalysis

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10.1002/anie.201008206

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title = "Chirality of glutathione surface coating affects the cytotoxicity of quantum dots",

abstract = "Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).",

keywords = "autophagy, chirality, cytotoxicity, fluorescence, quantum dots",

author = "Yiye Li and Yunlong Zhou and Wang, \{Hai Yan\} and Sarah Perrett and Yuliang Zhao and Zhiyong Tang and Guangjun Nie",

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month = jun,

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doi = "10.1002/anie.201008206",

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volume = "50",

pages = "5860--5864",

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T1 - Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

AU - Li, Yiye

AU - Zhou, Yunlong

AU - Wang, Hai Yan

AU - Perrett, Sarah

AU - Zhao, Yuliang

AU - Tang, Zhiyong

AU - Nie, Guangjun

PY - 2011/6/20

Y1 - 2011/6/20

N2 - Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).

AB - Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).

KW - autophagy

KW - chirality

KW - cytotoxicity

KW - fluorescence

KW - quantum dots

UR - https://www.scopus.com/pages/publications/79959232185

UR - https://www.scopus.com/inward/citedby.url?scp=79959232185&partnerID=8YFLogxK

U2 - 10.1002/anie.201008206

DO - 10.1002/anie.201008206

M3 - Article

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SN - 1433-7851

VL - 50

SP - 5860

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 26

ER -

Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

Abstract

Keywords

ASJC Scopus subject areas

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