Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

Yiye Li, Yunlong Zhou, Hai Yan Wang, Sarah Perrett, Yuliang Zhao, Zhiyong Tang, Guangjun Nie

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).

Original languageEnglish (US)
Pages (from-to)5860-5864
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number26
DOIs
StatePublished - Jun 20 2011

Keywords

  • autophagy
  • chirality
  • cytotoxicity
  • fluorescence
  • quantum dots

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Fingerprint

Dive into the research topics of 'Chirality of glutathione surface coating affects the cytotoxicity of quantum dots'. Together they form a unique fingerprint.

Cite this