Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

Yiye Li; Yunlong Zhou; Hai Yan Wang; Sarah Perrett; Yuliang Zhao; Zhiyong Tang; Guangjun Nie

doi:10.1002/anie.201008206

Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

Yiye Li, Yunlong Zhou, Hai Yan Wang, Sarah Perrett, Yuliang Zhao, Zhiyong Tang, Guangjun Nie

Research output: Contribution to journal › Article › peer-review

212 Scopus citations

Abstract

Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).

Original language	English (US)
Pages (from-to)	5860-5864
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	26
DOIs	https://doi.org/10.1002/anie.201008206
State	Published - Jun 20 2011

Keywords

autophagy
chirality
cytotoxicity
fluorescence
quantum dots

ASJC Scopus subject areas

Chemistry(all)
Catalysis

Access to Document

10.1002/anie.201008206

Cite this

@article{a023c272360b4c3bb750e26fe59c152a,

title = "Chirality of glutathione surface coating affects the cytotoxicity of quantum dots",

abstract = "Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).",

keywords = "autophagy, chirality, cytotoxicity, fluorescence, quantum dots",

author = "Yiye Li and Yunlong Zhou and Wang, {Hai Yan} and Sarah Perrett and Yuliang Zhao and Zhiyong Tang and Guangjun Nie",

year = "2011",

month = jun,

day = "20",

doi = "10.1002/anie.201008206",

language = "English (US)",

volume = "50",

pages = "5860--5864",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "Wiley",

number = "26",

}

TY - JOUR

T1 - Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

AU - Li, Yiye

AU - Zhou, Yunlong

AU - Wang, Hai Yan

AU - Perrett, Sarah

AU - Zhao, Yuliang

AU - Tang, Zhiyong

AU - Nie, Guangjun

PY - 2011/6/20

Y1 - 2011/6/20

N2 - Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).

AB - Choose your poison: Chiral CdTe quantum dots (QDs) coated with L- or D-glutathione (GSH) stabilizers exhibit differences in cytotoxicity although they have identical composition and size. D-GSH-QDs are less cytotoxic than L-GSH-QDs. The ability of QDs to induce cell death is correlated with their ability to induce autophagy, which is chirality-dependent (see picture).

KW - autophagy

KW - chirality

KW - cytotoxicity

KW - fluorescence

KW - quantum dots

UR - http://www.scopus.com/inward/record.url?scp=79959232185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959232185&partnerID=8YFLogxK

U2 - 10.1002/anie.201008206

DO - 10.1002/anie.201008206

M3 - Article

C2 - 21567671

AN - SCOPUS:79959232185

SN - 1433-7851

VL - 50

SP - 5860

EP - 5864

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 26

ER -

Chirality of glutathione surface coating affects the cytotoxicity of quantum dots

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this