Chimeric t-cell receptors for the targeting of cancer cells

Claudia Rössig, Malcolm Brenner

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Genetic engineering of human T lymphocytes to express tumor antigen-specific chimeric immune receptors is an attractive means for providing large numbers of effector cells for adoptive immunotherapy. Major mechanisms of tumor escape from immune recognition are efficiently bypassed. Although adoptive transfer of chimeric receptor-expressing peripheral blood-derived T lymphocytes has produced some anti-tumor activity in mice, the first clinical studies have revealed a disappointing lack of correlation between in vitro cytotoxicity and therapeutic efficacy. The most pertinent issue is that chimeric T cells fail to expand and rapidly lose their function in vivo. Potential strategies to enhance the therapeutic value of chimeric receptor-modified cells by preventing their functional inactivation in vivo are currently being investigated.

Original languageEnglish (US)
Pages (from-to)154-159
Number of pages6
JournalActa Haematologica
Volume110
Issue number2-3
DOIs
StatePublished - Nov 10 2003

Keywords

  • Adoptive immunotherapy
  • Costimulation
  • Cytotoxic T cells
  • Gene therapy
  • T cell receptor

ASJC Scopus subject areas

  • Hematology

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