Children’s Oncology Group (COG) Trials for Retinoblastoma

Dan S. Gombos, Anna T. Meadows, Murali Chintagumpala, Ira J. Dunkel, Debra Friedman, Julie Ann Stoner, Rima Jubran, Judith Grob Villablanca

Research output: Chapter in Book/Report/Conference proceedingChapter


For the past 30 years, retinoblastoma, a tumor that occurs in only 3 % of children with cancer, has been the subject of extensive molecular biologic research. However, apart from a short period in the 1970s, retinoblastoma has not been studied by any of the pediatric cooperative groups. The past decade has witnessed significant multidisciplinary prospective clinical and biologic studies of this rare pediatric neoplasm. The Children’s Oncology Group (COG) has successfully opened four clinical trials with a fifth recently approved. This chapter will review these ongoing prospective multicenter trials.

Original languageEnglish (US)
Title of host publicationClinical Ophthalmic Oncology
Subtitle of host publicationRetinoblastoma, Second Edition
PublisherSpringer Berlin Heidelberg
Number of pages9
ISBN (Electronic)9783662434512
ISBN (Print)9783662434505
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)


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