TY - JOUR
T1 - Childhood socioeconomic status is prospectively associated with surface morphometry in adulthood
AU - Dufford, Alexander J.
AU - Evans, Gary W.
AU - Liberzon, Israel
AU - Swain, James E.
AU - Kim, Pilyoung
N1 - Funding Information:
We thank Erika Blackburn, Sarah Garfinkel, S. Shaun Ho, and Robert Varney for assistance with data collection. The current study was supported by National Institutes of Health Grant RC2MD004767 (GWE, IL, JES), R01HD090068 (PK), R01DA074336 (JES), T32MH18268 (AJD), the William T. Grant Foundation, the John D. and Catherine T. MacArthur Foundation Network on Socioeconomic Status and Health, and the Robert Wood Johnson Foundation.
Publisher Copyright:
© 2021 Wiley Periodicals LLC
PY - 2021/7
Y1 - 2021/7
N2 - Childhood socioeconomic status (SES) has been associated with brain cortex surface area in children. However, the extent to which childhood SES is prospectively associated with brain morphometry in adulthood is unclear. We tested whether childhood SES (income-to-needs ratio averaged across ages 9, 13, and 17) is prospectively associated with cortical surface morphometry in adulthood. Average childhood income-to-needs ratio had a positive, prospective association with cortical thickness in adulthood in the precentral gyrus, postcentral gyrus, and caudal middle frontal gyrus (p <.05, FWE corrected). Childhood income-to-needs ratio also had a positive, prospective association with cortical surface area in adulthood in multiple regions, including the rostral and caudal middle frontal gyri and superior frontal gyrus (p <.05, FWE corrected). Concurrent income-to-needs ratio (measured at age 24) was not associated with cortical thickness or surface area in adulthood. The results underscore the importance of addressing poverty in childhood for brain morphological development.
AB - Childhood socioeconomic status (SES) has been associated with brain cortex surface area in children. However, the extent to which childhood SES is prospectively associated with brain morphometry in adulthood is unclear. We tested whether childhood SES (income-to-needs ratio averaged across ages 9, 13, and 17) is prospectively associated with cortical surface morphometry in adulthood. Average childhood income-to-needs ratio had a positive, prospective association with cortical thickness in adulthood in the precentral gyrus, postcentral gyrus, and caudal middle frontal gyrus (p <.05, FWE corrected). Childhood income-to-needs ratio also had a positive, prospective association with cortical surface area in adulthood in multiple regions, including the rostral and caudal middle frontal gyri and superior frontal gyrus (p <.05, FWE corrected). Concurrent income-to-needs ratio (measured at age 24) was not associated with cortical thickness or surface area in adulthood. The results underscore the importance of addressing poverty in childhood for brain morphological development.
KW - childhood
KW - longitudinal
KW - socioeconomic status
KW - surface morphometry
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U2 - 10.1002/dev.22096
DO - 10.1002/dev.22096
M3 - Article
C2 - 33432574
AN - SCOPUS:85099112776
VL - 63
SP - 1589
EP - 1596
JO - Developmental Psychobiology
JF - Developmental Psychobiology
SN - 0012-1630
IS - 5
ER -