Chemotherapy and Radiofrequency-Induced Mild Hyperthermia Combined Treatment of Orthotopic Pancreatic Ductal Adenocarcinoma Xenografts

Martyna Krzykawska-Serda, Mahdi S. Agha, Jason Chak Shing Ho, Matthew J. Ware, Justin J. Law, Jared M. Newton, Lam Nguyen, Steven A. Curley, Stuart J. Corr

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with pancreatic ductal adenocarcinomas (PDAC) have one of the poorest survival rates of all cancers. The main reason for this is related to the unique tumor stroma and poor vascularization of PDAC. As a consequence, chemotherapeutic drugs, such as nab-paclitaxel and gemcitabine, cannot efficiently penetrate into the tumor tissue. Non-invasive radiofrequency (RF) mild hyperthermia treatment was proposed as a synergistic therapy to enhance drug uptake into the tumor by increasing tumor vascular inflow and perfusion, thus, increasing the effect of chemotherapy. RF-induced hyperthermia is a safer and non-invasive technique of tumor heating compared to conventional contact heating procedures. In this study, we investigated the short- and long-term effects (~20 days and 65 days, respectively) of combination chemotherapy and RF hyperthermia in an orthotopic PDAC model in mice. The benefit of nab-paclitaxel and gemcitabine treatment was confirmed in mice; however, the effect of treatment was statistically insignificant in comparison to saline treated mice during long-term observation. The benefit of RF was minimal in the short-term and completely insignificant during long-term observation.

Original languageEnglish (US)
Pages (from-to)664-671
Number of pages8
JournalTranslational Oncology
Volume11
Issue number3
DOIs
StatePublished - Jun 2018

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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