Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis: In vitro, intracellular, and in vivo studies

Chinnaswamy Jagannath; M. Venkata Reddy; Subramanian Kailasam; J. F. O'Sullivan; Pattisapu R.J. Gangadharam

doi:10.1164/ajrccm.151.4.7697235

Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis: In vitro, intracellular, and in vivo studies

Chinnaswamy Jagannath, M. Venkata Reddy, Subramanian Kailasam, J. F. O'Sullivan, Pattisapu R.J. Gangadharam

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Abstract

Clofazimine (CFM), a riminophenazine drug, is primarily used in therapy for leprosy and Mycobacterium avium infections. With an objective of identifying drugs active against Mycobacterium tuberculosis, including those with multi-drug resistance, we investigated CFM and nine of its chemical analogues. Among these, B746 and B4101 had better activity than CFM against six drug-susceptible and nine single/multiple drug-resistant M. tuberculosis strains. B746 also showed slightly better activity than CFM against intracellular M. tuberculosis in J774A.1 macrophages and was comparable to CFM in its in vivo activity against experimental tuberculosis in C57BL/6 mice. Interestingly, it caused less pigmentation in internal organs.

Original language	English (US)
Pages (from-to)	1083-1086
Number of pages	4
Journal	American journal of respiratory and critical care medicine
Volume	151
Issue number	4
DOIs	https://doi.org/10.1164/ajrccm.151.4.7697235
State	Published - Apr 1995

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine

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Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis : In vitro, intracellular, and in vivo studies. / Jagannath, Chinnaswamy; Reddy, M. Venkata; Kailasam, Subramanian et al.

In: American journal of respiratory and critical care medicine, Vol. 151, No. 4, 04.1995, p. 1083-1086.

Research output: Contribution to journal › Article › peer-review

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Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis: In vitro, intracellular, and in vivo studies

Abstract

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