TY - JOUR
T1 - Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice
AU - Yan, Ying
AU - Cook, Julie
AU - McQuillan, Jay
AU - Zhang, Guifang
AU - Hitzman, Cory J.
AU - Wang, Yian
AU - Wiedmann, Timothy S.
AU - You, Ming
N1 - Funding Information:
Address all correspondence to: Ming You, Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University in St. Louis, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail: [email protected] 1This work was supported, in part, by grants (R01 CA113793 and P01 CA9696401) from the National Cancer Institute, National Institutes of Health. 2Present address: Boston Scientific, Inc., Maple Grove, MN, USA. Received 2 February 2007; Revised 8 March 2007; Accepted 12 March 2007.
PY - 2007/5
Y1 - 2007/5
N2 - Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.
AB - Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by ∼ 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.
KW - Aerosol
KW - Chemoprevention
KW - Lung tumorigenesis
KW - Mouse
KW - Polyphenon E
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U2 - 10.1593/neo.07160
DO - 10.1593/neo.07160
M3 - Article
C2 - 17534445
AN - SCOPUS:34249002243
SN - 1522-8002
VL - 9
SP - 401
EP - 405
JO - Neoplasia
JF - Neoplasia
IS - 5
ER -