Chemical-induced estrogenicity

Stephen H. Safe, Shaheen Khan, Fei Wu, Xiangrong Li

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


17β-estradiol (E2) and the related steroidal hormones play an important role in multiple physiological processes. However, these hormones are risk factors for hormone-dependent diseases including breast and endometrial cancer. Inappropriate exposures (high or low) to estrogens can also lead to adverse health effects. The identification of estrogenic compounds in the environment, coupled with human exposures to these compounds, has generated public, regulatory, and scientific concern regarding their potential hormonal toxicity to humans and wildlife. This chapter focuses on chemical-induced estrogenicity and the potential toxicological impacts of these compounds. It also describes several different structural classes of synthetic estrogenic compounds, phytoestrogens, and estrogens/antiestrogens such as diethylstilbestrol and tamoxifen that are used as pharmaceutical agents. In addition, the mechanism of estrogen action and implications for risk assessment of these compounds are also discussed. These factors highlight the challenges faced by scientists and regulators in addressing the health risks and benefits of estrogenic compounds.

Original languageEnglish (US)
Title of host publicationVeterinary Toxicology
Subtitle of host publicationBasic and Clinical Principles
Number of pages12
ISBN (Print)9780123704672
StatePublished - Mar 14 2007

ASJC Scopus subject areas

  • Medicine(all)


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