Characterizing dynamic immune cell activity after stimulation on nanofabricated biomaterial patterns

R. N. Orth, T. G. Clark, Harold G. Craighead, M. J.B.F. Flaminio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Nanofabricated biomaterial microdomains were patterned on planar silicon substrates creating in vitro systems to characterize the complex interactions between cell surface receptors and submicron targets. The model experimental setup consisted of T cells, B cells, and macrophages incubated on patterned bacteria and mitogen. The technique offered a means to characterize cellular interactions occurring at the submicron resolution after stimulation with microstimuli. Epifluorescence and SEM imaging permitted detailed views of the cellular activity on patterns where the antigenic concentration, feature size, and media volume were comparable to a physiological microenvironment.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004


OtherTransactions - 7th World Biomaterials Congress

ASJC Scopus subject areas

  • Engineering(all)


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