Characterization of the opposite-strand genes from the mouse bidirectionally transcribed HTF9 locus

Alessandro Bressan, Maria Patrizia Somma, Joe Lewis, Carlo Santolamazza, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Patrizia Lavia

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The mouse HTF9 locus contains two genes that are bidirectionally transcribed with opposite polarity from a shared CpG-rich island. Both genes were previously shown to be expressed in a housekeeping fashion in mouse. We have now determined the molecular organization of the genes over 12 kb surrounding the island. In addition, we show that the HTF9 locus resides in the proximal region of mouse chromosome 16. We have sequenced the cDNAs corresponding to both divergent transcripts. Both genes appear to code for novel proteins that are structurally unrelated to each other. Finally, we show that both genes are highly conserved and efficiently expressed in human cells.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalGene
Volume103
Issue number2
DOIs
StatePublished - Jul 22 1991

Keywords

  • bidirectional transcription
  • CpG island
  • gene molecular organization
  • housekeeping expression
  • interspecific backcross mapping
  • nucleotide sequence

ASJC Scopus subject areas

  • Genetics

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