Characterization of the Manila family of Mycobacterium tuberculosis

James T. Douglas; Lishi Qian; Jaime C. Montoya; James M. Musser; Jan D.A. Van Embden; Dick Van Soolingen; Kristin Kremer

doi:10.1128/JCM.41.6.2723-2726.2003

Characterization of the Manila family of Mycobacterium tuberculosis

James T. Douglas, Lishi Qian, Jaime C. Montoya, James M. Musser, Jan D.A. Van Embden, Dick Van Soolingen, Kristin Kremer

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Forty-eight Mycobacterium tuberculosis strains were obtained from patients living in metropolitan Manila, Republic of the Philippines. Three molecular typing methods, IS6110 restriction fragment length polymorphism, spoligotyping, and DNA sequencing of the oxyR, gyrA, and katG loci, established that these strains have restricted diversity and are members of a related genetic group of organisms. Comparison of the DNA fingerprint patterns with those in international databases confirmed the uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis.

Original language	English (US)
Pages (from-to)	2723-2726
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	41
Issue number	6
DOIs	https://doi.org/10.1128/JCM.41.6.2723-2726.2003
State	Published - Jun 1 2003

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/JCM.41.6.2723-2726.2003

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abstract = "Forty-eight Mycobacterium tuberculosis strains were obtained from patients living in metropolitan Manila, Republic of the Philippines. Three molecular typing methods, IS6110 restriction fragment length polymorphism, spoligotyping, and DNA sequencing of the oxyR, gyrA, and katG loci, established that these strains have restricted diversity and are members of a related genetic group of organisms. Comparison of the DNA fingerprint patterns with those in international databases confirmed the uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis.",

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AU - Qian, Lishi

AU - Montoya, Jaime C.

AU - Musser, James M.

AU - Van Embden, Jan D.A.

AU - Van Soolingen, Dick

AU - Kremer, Kristin

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AB - Forty-eight Mycobacterium tuberculosis strains were obtained from patients living in metropolitan Manila, Republic of the Philippines. Three molecular typing methods, IS6110 restriction fragment length polymorphism, spoligotyping, and DNA sequencing of the oxyR, gyrA, and katG loci, established that these strains have restricted diversity and are members of a related genetic group of organisms. Comparison of the DNA fingerprint patterns with those in international databases confirmed the uniqueness of this group of isolates, which we designate the Manila family of M. tuberculosis.

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Characterization of the Manila family of Mycobacterium tuberculosis

Abstract

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